Affinity Improvement of a Cancer-Targeted Antibody through Alanine-Induced Adjustment of Antigen-Antibody Interface. Yamashita T, Mizohata E, Nagatoishi S, Watanabe T, Nakakido M, Iwanari H, Mochizuki Y, Nakayama T, Kado Y, Yokota Y, Matsumura H, Kawamura T, Kodama T, Hamakubo T, Inoue T, Fujitani H, Tsumoto K. Structure. Structure 27, 1–9, March 5, 2019. [Epub ahead of print] 2018 Nov 20. pii: S0969-2126(18)30421-0. doi: 10.1016/j.str.2018.11.002. PMID 30595454

Launching the C-HPP pilot project for functional characterization of identified proteins with no known function. Young-Ki Paik, Lydie Lane, Takeshi Kawamura, Yu-Ju Chen, Je-Yoel Cho, Joshua LaBaer, Jong Shin Yoo, Gilberto B. Domont, Fernando Corrales, Gilbert S Omenn, Alexander Archakov, Sergio Encarnación- Guevara, Siqi Liu, Ghasem Hosseini Salekdeh, Jin-Young Cho, Chae-Yeon Kim, and Christopher M Overall. J Proteome Res. 2018 Nov 29. doi: 10.1021/acs.jproteome.8b00383. [Epub ahead of print] PMID: 30269496

Hierarchical roles of mitochondrial Papi and Zucchini in Bombyx germline piRNA biogenesis. Nishida KM, Sakakibara K, Iwasaki YW, Yamada H, Murakami R, Murota Y, Kawamura T, Kodama T, Siomi H, Siomi MC. Nature. 2018 Mar 8;555(7695):260-264. doi: 10.1038/nature25788. Epub 2018 Feb 28. PMID: 29489748

Development of Drug Discovery Screening System by Molecular Interaction Kinetics Mass Spectrometry. Obi N, Fukuda T, Nakayama N, Ervin J, Bando Y, Nishimura T, Nagatoishi S, Tsumoto K, Kawamura T. Rapid Commun Mass Spectrom. 2018 Feb 14. doi: 10.1002/rcm.8083. [Epub ahead of print] PMID: 29441684

O-GlcNAc on PKCζ Inhibits the FGF4-PKCζ-MEK-ERK1/2 Pathway via Inhibition of PKCζ Phosphorylation in Mouse Embryonic Stem Cells. Taichi Miura, Masahiko Kume, Takeshi Kawamura, Kazuo Yamamoto, Takao Hamakubo, and Shoko Nishihara. Stem Cell Reports. 2017 Dec 12. pii: S2213-6711(17)30514-3. doi: 10.1016/j.stemcr.2017.11.007.

Degradation of human Lipin-1 protein by BTRC E3 ubiquitin ligase. Kenji Ishimoto, Ayaka Hayase, Fumiko Kumagai, Megumi Kawai, Hiroko Okuno, Nobumasa Hino, Yoshiaki Okada, Takeshi Kawamura, Toshiya Tanaka, Takao Hamakubo, Juro Sakai, Tatsuhiko Kodama, Keisuke Tachibana and Takefumi Doi. Biochem Biophys Res Commun. 2017 Jun 17;488(1):159-164. doi: 10.1016/j.bbrc.2017.04.159. Epub 2017 May 5.

Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia. Hiroshi Okuda, Boban Stanojevic, Akinori Kanai, Takeshi Kawamura, Satoshi Takahashi, Hirotaka Matsui, Akifumi Takaori-Kondo, Akihiko Yokoyama. The Journal of Clinical Investegation 2017 May 1;127(5):1918-1931. doi: 10.1172/JCI91406. Epub 2017 Apr 10.

Plasma Irradiation Effects to Intra-Abdominal Organ Compared with Adhesion Mouse Model. Keita Soda, Hiroharu Yamashita, Kyungho Chang, Takeshi Kawamura, Takao Hamakubo and Nobuyuki Shimizu. Plasma Medicine 7(4):347–381 (2017)

Biological implications of somatic DDX41 p.R525H mutation in acute myeloid leukemia. Kadono M, Kanai A, Nagamachi A, Shinriki S, Kawata J, Iwato K, Kyo T, Oshima K, Yokoyama A, Kawamura T, Nagase R, Inoue D, Kitamura T, Inaba T, Ichinohe T, Matsui H.Exp Hematol. 2016 Aug;44(8):745-754.e4. doi: 10.1016/j.exphem.2016.04.017. Epub 2016 May 9. PMID: 27174803

PGE2 induced in and released by dying cells functions as an inhibitory DAMP. Sho Hangai, Tomoka Ao, Yoshitaka Kimura, Kosuke Matsuki, Takeshi Kawamura, Hideo Negishi, Junko Nishio, Tatsuhiko Kodama, Tadatsugu Taniguchi and Hideyuki Yanai. Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):3844-9. doi: 10.1073/pnas.1602023113. Epub 2016 Mar 21. PMID: 27001836

Suppression of Slit2/Robo1 mediated HUVEC migration by Robo4. Enomoto S, Mitsui K, Kawamura T, Iwanari H, Daigo K, Horiuchi K, Minami T, Kodama T, Hamakubo T. Biochem Biophys Res Commun. 2016 Jan 22;469(4):797-802. doi: 10.1016/j.bbrc.2015.12.075. Epub 2015 Dec 20. PMID: 26713366

Epiregulin Recognition Mechanisms by Anti-epiregulin Antibody 9E5: STRUCTURAL, FUNCTIONAL, AND MOLECULAR DYNAMICS SIMULATION ANALYSES. Kado Y, Mizohata E, Nagatoishi S, Iijima M, Shinoda K, Miyafusa T, Nakayama T, Yoshizumi T, Sugiyama A, Kawamura T, Lee YH, Matsumura H, Doi H, Fujitani H, Kodama T, Shibasaki Y, Tsumoto K, Inoue T. J Biol Chem. 2016 Jan 29;291(5):2319-30. doi: 10.1074/jbc.M115.656009. Epub 2015 Dec 1. PMID: 26627827

Analysis of the subcellular localization of the human histone methyltransferase SETDB1. Tachibana K, Gotoh E, Kawamata N, Ishimoto K, Uchihara Y, Iwanari H, Sugiyama A, Kawamura T, Mochizuki Y, Tanaka T, Sakai J, Hamakubo T, Kodama T, Doi T. Biochem Biophys Res Commun. 2015 Oct 2;465(4):725-31. doi: 10.1016/j.bbrc.2015.08.065. Epub 2015 Aug 18. PMID: 26296461

Middle-Down and Chemical Proteomic Approaches to Reveal Histone H4 Modification Dynamics in Cell Cycle: Label-Free Semi-Quantification of Histone Tail Peptide Modifications Including Phosphorylation and Highly Sensitive Capture of Histone PTM Binding Proteins Using Photo-Reactive Crosslinkers. Kazuki Yamamoto, Yoko Chikaoka, Gosuke Hayashi, Ryosuke Sakamoto, Ryuji Yamamoto, Akira Sugiyama, Tatsuhiko Kodama, Akimitsu Okamoto, and Takeshi Kawamura. Mass Spectrometry Vol. 4 (2015) No. 1 p. A0039 Published online July 14, 2015

A proteomic profiling of laser-microdissected lung adenocarcinoma cells of early lepidic-types. Kato Y, Nakamura H, Tojo H, Nomura M, Nagao T, Kawamura T, Kodama T, Ohira T, Ikeda N, Fehniger T, Marko-Varga G, Nishimura T, Kato H. Clin Transl Med. 2015 Dec;4(1):64. doi: 10.1186/s40169-015-0064-3. Epub 2015 Jul 3.PMID: 26162278

An improvement on mass spectrometry-based epigenetic analysis of large histone-derived peptides by using the Ionization Variable Unit interface. Fukuda T, Hike H, Usui F, Bando Y, Nishimura T, Kodama T, Kawamura T. Anal Biochem. 2015 Jun 5;486:14-16. doi: 10.1016/j.ab.2015.06.002. [Epub ahead of print]PMID: 26050628

JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis. Yohei Abe, Royhan Rozqie, Yoshihiro Matsumura, Takeshi Kawamura, Ryo Nakaki, Yuya Tsurutani, Kyoko Tanimura-Inagaki, Akira Shiono, Kenta Magoori, Kanako Nakamura, Shotaro Ogi, Shingo Kajimura, Hiroshi Kimura, Toshiya Tanaka, Kiyoko Fukami, Timothy Osborne, Tatsuhiko Kodama, Hiroyuki Aburatani, Takeshi Inagaki, and Juro Sakai. Nat Commun. 2015 May 7;6:7052. doi: 10.1038/ncomms8052. PMID: 25948511

The FBXL10/KDM2B Scaffolding Protein Associates with Novel Polycomb Repressive Complex-1 to Regulate Adipogenesis. Inagaki T, Iwasaki S, Matsumura Y, Kawamura T, Tanaka T, Abe Y, Yamasaki A, Tsurutani Y, Yoshida A, Chikaoka Y, Nakamura K, Magoori K, Nakaki R, Osborne TF, Fukami K, Aburatani H, Kodama T, Sakai J. J Biol Chem. 2015 Feb 13;290(7):4163-77.

Crystal structure of streptavidin mutant with low immunogenicity. Kawato T, Mizohata E, Meshizuka T, Doi H, Kawamura T, Matsumura H, Yumura K, Tsumoto K, Kodama T, Inoue T, Sugiyama A. J Biosci Bioeng. 2015 Jun;119(6):642-7. doi: 10.1016/j.jbiosc.2014.10.025. Epub 2014 Nov 26. PMID: 25434833

Clinical initiatives linking Japanese and Swedish healthcare resources on cancer studies utilizing Biobank Repositories. Toshihide Nishimura, Takeshi Kawamura, Yutaka Sugihara, Yasuhiko Bando, Shigeru Sakamoto, Masaharu Nomura, Norihiko Ikeda, Tatsuo Ohira, Junichiro Fujimoto, Hiromasa Tojo, Takao Hamakubo, Tatsuhiko Kodama, Roland Andersson, Thomas E Fehniger, Harubumi Kato and Gyorgy Marko-Varga. Clinical and Translational Midicine 2014 Nov 22;3(1):61.

Direct Evidence for Pitavastatin Induced Chromatin Structure Change in the KLF4 Gene in Endothelial Cells. Maejima T, Inoue T, Kanki Y, Kohro T, Li G, Ohta Y, Kimura H, Kobayashi M, Taguchi A, Tsutsumi S, Iwanari H, Yamamoto S, Aruga H, Dong S, Stevens JF, Poh HM, Yamamoto K, Kawamura T, Mimura I, Suehiro J, Sugiyama A, Kaneki K, Shibata H, Yoshinaka Y, Doi T, Asanuma A, Tanabe S, Tanaka T, Minami T, Hamakubo T, Sakai J, Nozaki N, Aburatani H, Nangaku M, Ruan X, Tanabe H, Ruan Y, Ihara S, Endo A, Kodama T, Wada Y. PLoS One. 2014 May 5;9(5):e96005

MLL fusion proteins link transcriptional coactivators to previously active CpG-rich promoters. Okuda H, Kawaguchi M, Kanai A, Matsui H, Kawamura T, Inaba T, Kitabayashi I, Yokoyama A. Nucleic Acids Res. 2014 Apr;42(7):4241-56. doi: 10.1093/nar/gkt1394. Epub 2014 Jan 23. PMID: 24465000

Control of histone H3 lysine 9 (H3K9) methylation state via cooperative two-step demethylation by Jumonji domain containing 1A (JMJD1A) homodimer. Goda S, Isagawa T, Chikaoka Y, Kawamura T, Aburatani H. J Biol Chem. 2013 Dec 27; 288(52): 36948-56. doi: 10.1074/jbc.M113.492595. Epub 2013 Nov 8. PMID: 24214985

Identification of Wilms' tumor 1-associating protein complex and its role in alternative splicing and the cell cycle. Horiuchi K, Kawamura T, Iwanari H, Ohashi R, Naito M, Kodama T, Hamakubo T. J Biol Chem. 2013 Nov 15;288(46):33292-302. doi: 10.1074/jbc.M113.500397. Epub 2013 Oct 7. PMID: 24100041

Uhrf1-dependent ubiquitylation of histone H3 at lysine 23 couples maintenance DNA methylation and DNA replication. Atsuya Nishiyama, Luna Yamaguchi1 Jafar Sharif, Yoshikazu Johmura, Takeshi Kawamura, Keiko Nakanishi, Shintaro Shimamura, Tatsuhiko Kodama, Fuyuki Ishikawa, Haruhiko Koseki and Makoto Nakanishi Nature (2013) Oct 10;502(7470):249-253. doi: 10.1038/nature12488. Epub 2013 Sep 8. PMID: 24013172

Modification of p115RhoGEF Ser330 regulates its RhoGEF activity. Chow CR, Suzuki N, Kawamura T, Hamakubo T, Kozasa T. Cell Signal. 2013 Nov;25(11):2085-92. doi: 10.1016/j.cellsig.2013.06.012. Epub 2013 Jun 29. PMID: 23816534

Phosphatidylinositol 3-phosphatase myotubularin-related protein (MTMR6) is regulated by small GTPase Rab1B in the early secretory and autophagic pathways. Mochizuki Y, Ohashi R, Kawamura T, Iwanari H, Kodama T, Naito M and Hamakubo T. J Biol Chem. 2013 Jan 11;288(2):1009-21. Epub 2012 Nov 27. PMID: 23188820

Relationship between ATM and ribosomal protein S6 revealed by the chemical inhibition of Ser/Thr protein phosphatase type 1. Li Y, Mitsuhashi S, Ikejo M, Miura N, Kawamura T, Hamakubo T, Ubukata M. Biosci Biotechnol Biochem. 2012;76(3):486-94. PMID: 22451389

The proteomic profile of circulating pentraxin 3 (PTX3) complex in sepsis demonstrates the interaction with azurocidin 1 and other components of neutrophil extracellular traps. Daigo K, Yamaguchi N, Kawamura T, Matsubara K, Jiang S, Ohashi R, Sudou Y, Kodama T, Naito M, Inoue K, Hamakubo T. Mol Cell Proteomics. 2012 Jun;11(6):M111.015073. doi: 10.1074/mcp.M111.015073. Epub 2012 Jan 25. PMID: 22278372

Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study. Nomura M, Fukuda T, Fujii K, Kawamura T, Tojo H, Kihara M, Bando Y, Gazdar AF, Tsuboi M, Oshiro H, Nagao T, Ohira T, Ikeda N, Gotoh N, Kato H, Marko-Varga G, Nishimura T. J Clin Bioinforma. 2011 Sep 3;1(1):23.PMID: 21888658

TLS and PRMT1 synergistically coactivate transcription at the survivin promoter through TLS arginine methylation. Kun Du, Shigeki Arai, Takeshi Kawamura, Akio Matsushita, Riki Kurokawa. Biochem Biophys Res Commun. 2011 Jan 28;404(4):991-6. Epub 2010 Dec 25.

A Clinician View of Proteomic Studies in the Light of the Experience in the Lung Cancer in Japanese Healthcare. Kato H, Nishimura T, Hirano T, Nomura M, Tojo H, Fujii K, Kawamura T, Mikami S, Kihara M, Bando Y, Tsuboi M, Ikeda N, Varga GM. J Proteome Res. 2010 Dec 8. Epub 2011 Jan 7;10(1):51-7.

PROTEOMIC ANALYSIS OF NATIVE HEPATOCYTE NUCLEAR FACTOR-4α (HNF4α) ISOFORMS, PHOSPHORYLATION STATUS, AND INTERACTIVE COFACTORS. Kenji Daigo*, Takeshi Kawamura*, Yoshihiro Ohta1, Riuko Ohashi, Satoshi Katayose, Toshiya Tanaka, Hiroyuki Aburatani, Makoto Naito, Tatsuhiko Kodama, Sigeo Ihara and Takao Hamakubo (* equally contributed). J Biol Chem. 2011 Jan 7;286(1):674-86. Epub 2010 Nov 3. (Erratum in J Biol Chem. 2013 Aug 16;288(33):24161.)

Human ROBO1 Is Cleaved by Metalloproteinases and g-Secretase and Migrates to the Nucleus in Cancer Cells. Motoaki Seki, Akira Watanabe, Satoshi Enomoto, Takeshi Kawamura, Hirotaka Ito, Tatsuhiko Kodama, Takao Hamakubo and Hiroyuki Aburatani FEBS letter. 2010 Jul 2;584(13):2909-15. Epub 2010 May 13. PMID: 20471383

Functional involvement of Tudor and dPRMT5 in the piRNA processing pathway in Drosophila germlines. Kazumichi M Nishida, Tomoko N Okada, Takeshi Kawamura, Toutai Mituyama, Yoshinori Kawamura1, Sachi Inagaki, Haidong Huang, Dahua Chen, Tatsuhiko Kodama, Haruhiko Siomi and Mikiko C Siomi EMBO journal. 2009 Dec 16;28(24):3820-31. PMID: 19959991

Proteomic analysis of laser-microdissected paraffin-embedded tissues: (1) Stage-related protein candidates upon non-metastatic lung adenocarcinoma. Takeshi Kawamura*, Masaharu Nomura*, Hiromasa Tojo, Kiyonaga Fujii, Hiroko Hamasaki, Sayaka Mikami, Yasuhiko Bando, Harubumi Kato and Toshihide Nishimura (* equally contributed). J Proteomics. 2010 Apr 18;73(6):1089-99. Epub 2009 Nov 27. PMID: 19948256

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses. Hideyuki Yanai, Tatsuma Ban, ZhiChao Wang, Myoung Kwon Choi, Takeshi Kawamura, Hideo Negishi, Makoto Nakasato, Yan Lu, Sho Hangai, Ryuji Koshiba, David Savitsky, Lorenza Ronfani, Shizuo Akira, Marco E. Bianchi, Kenya Honda, Tomohiko Tamura, Tatsuhiko Kodama & Tadatsugu Taniguchi. Nature. 2009 Nov 5;462(7269):99-103. PMID: 19890330

Annexin II represents metastatic potential in clear-cell renal cell carcinoma. Ohno Y, Izumi M, Kawamura T, Nishimura T, Mukai K, Tachibana M. Br J Cancer. 2009 Jul 21;101(2):287-94. Epub 2009 Jun 9.PMID: 19513064

Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion. Tanuma N, Nomura M, Ikeda M, Kasugai I, Tsubaki Y, Takagaki K, Kawamura T, Yamashita Y, Sato I, Sato M, Katakura R, Kikuchi K, Shima H. Oncogene. 2009 Feb 5;28(5):752-61. Epub 2008 Dec 1. PMID: 19043453

Nuclear inhibitor of protein phosphatase-1 (NIPP1) directs protein phosphatase-1 (PP1) to dephosphorylate the U2 small nuclear ribonucleoprotein particle (snRNP) component, spliceosome-associated protein 155 (Sap155). Tanuma N, Kim SE, Beullens M, Tsubaki Y, Mitsuhashi S, Nomura M, Kawamura T, Isono K, Koseki H, Sato M, Bollen M, Kikuchi K, Shima H. J Biol Chem. 2008 Dec 19;283(51):35805-14. Epub 2008 Oct 8.PMID: 18842582

Characterization and gene expression analysis of novel matched primary and metastatic renal cell carcinoma cell lines. Ohno Y, Izumi M, Tachibana M, Kawamura T, Yoshioka K, Aoyagi T, Ohori M, Namiki K, Sakamoto N, Nakagami Y, Hatano T, Akimoto S, Nishimura T. Oncol Rep. 2008 Sep;20(3):501-9.PMID: 18695898

Alteration of cystatin C in the cerebrospinal fluid of multiple sclerosis. Nakashima I, Fujinoki M, Fujihara K, Kawamura T, Nishimura T, Nakamura M, Itoyama Y. Ann Neurol. 2007 Aug;62(2):197-200; discussion 205. PMID: 16958112

Personalized medicine and proteomics: lessons from non-small cell lung cancer. Marko-Varga G, Ogiwara A, Nishimura T, Kawamura T, Fujii K, Kawakami T, Kyono Y, Tu HK, Anyoji H, Kanazawa M, Akimoto S, Hirano T, Tsuboi M, Nishio K, Hada S, Jiang H, Fukuoka M, Nakata K, Nishiwaki Y, Kunito H, Peers IS, Harbron CG, South MC, Higenbottam T, Nyberg F, Kudoh S, Kato H. J Proteome Res. 2007 Aug;6(8):2925-35. Epub 2007 Jul 17. PMID: 17636986

Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitination. Lim MK, Kawamura T, Ohsawa Y, Ohtsubo M, Asakawa S, Takayanagi A, Shimizu N. Exp Cell Res. 2007 Aug 1;313(13):2858-74. Epub 2007 Apr 20.PMID: 17512523

Multidimensional protein profiling technology and its application to human plasma proteome. Fujii K, Nakano T, Kawamura T, Usui F, Bando Y, Wang R, Nishimura T. J Proteome Res. 2004 Jul-Aug;3(4):712-8. PMID: 15359723

Identification of 66 kDa phosphoprotein associated with motility initiation of hamster spermatozoa. Masakatsu Fujinoki, Takeshi Kawamura, Toshifusa Toda, Tadashi Ishimoda-Takagi, Hideki Ohtake, Nobuyoshi Shimizu, Makoto Okuno. Reproductive Medicine and Biology 3: 133-139, 2004.

Identification of 36 kDa phosphoprotein in fibrous sheath of hamster spermatozoa. Masakatsu Fujinoki, Takeshi Kawamura, Toshifusa Toda, Hideki Ohtake, Tadashi Ishimoda-Takagi, Nobuyoshi Shimizu, Sadao Yamaoka and Makoto Okuno. Comparative Biochemistry and Physiology 137B: 509-520, 2004 PMID: 15082001

Identification of the 58-kDa phosphoprotein associated with motility initiation of hamster spermatozoa. Masakatsu Fujinoki, Takeshi Kawamura, Toshifusa Toda, Hideki Ohtake, Nobuyoshi Shimizu, Sadao Yamaoka and Makoto Okuno. Journal of Biochemistry (Tokyo) 134: 559-565, 2003 PMID: 14607983

Identification of 36k-Da Flagellar Phosphoproteins Associated with Hamster Sperm Motility . Masakatsu Fujinoki, Takeshi Kawamura, Toshifusa Toda, Hideki Ohtake, Tadashi Ishimoda-Takagi, Nobuyoshi Shimizu, Sadao Yamaoka and Makoto Okuno. Journal of Biochemistry (Tokyo) 133: 361-369, 2003. PMID: 12761172

The spiroketals containing a benzyloxymethyl moiety at C8 position showed the most potent apoptosis-inducing activity. Shinya Mitsuhashi, Hiroshi Shima, Takeshi Kawamura, Kunimi Kikuchi, Masato Oikawa, Akitami Ichihara and Hideaki Oikawa. Biochemical & Medicinal Chemistry Letter 9: 2007-2012, 1999 PMID: 10450971

Thyrsiferyl 23-acetate and its derivatives induce apoptosis in various T- and B-leukemia cells. Shu-ichi Matsuzawa, Takeshi Kawamura, Shinya Mitsuhashi, Teruaki Suzuki, Yoshihide Matsuo, Minoru Suzuki, Yusuke Mizuno, and Kunimi Kikuchi. Biochemical & Medicinal Chemistry 7: 381-387, 1999. PMID: 10218832

Different moieties of tautomycin involved in protein phosphatase inhibition and induction of apoptosis. Takeshi Kawamura, Shu-ichi Matsuzawa, Yusuke Mizuno, Kunimi Kikuchi, Hideaki Oikawa, Masato Oikawa, Makoto Ubukata, and Akitami Ichihara. Biochemical Pharmacology 55: 995-1003, 1998. PMID: 9605423

Alterations in type-1 serine/threonine protein phosphatase PP1α in response to B-cell receptor stimulation. Norio Takizawa, Yusuke Mizuno, Masakazu Komatsu, Shu-ichi Matsuzawa, Takeshi Kawamura, Naoyuki Inagaki, Masaki Inagaki, and Kunimi Kikuchi. Journal of Biochemistry (Tokyo) 122: 730-737, 1997. PMID: 9399575

Relationships of subunits of type-1 serine/threonine protein phosphatase to morphology and aggregation of B cells. Norio Takizawa, Masakazu Komatsu, Yusuke Mizuno, Takeshi Kawamura, Masaki Ito, Takeshi Nakano, and Kunimi Kikuchi. Journal of Biochemistry (Tokyo) 122: 723-729, 1997. PMID: 9399574

Thyrsiferyl 23-acetate is a novel specific inhibitor of protein phosphatase PP2A. Shu-ici Matsuzawa, Teruaki Suzuki, Minoru Suzuki, Akio Matsuda, Takeshi Kawamura, Yusuke Mizuno, and Kunimi Kikuchi. FEBS Letter 356: 272-274, 1994. PMID: 7805852

Increases in protein phosphatase 2B activity in lymphoid tissues and T-lymphocytes of autoimmune MRL/MpJ-lpr/lpr mice. Chika Katagiri, Takeshi Kawamura, Shu-ichi Matsuzawa, Yusuke Mizuno, Sueo Matsumura, and Kunimi Kikuchi. Journal of Biochemistry (Tokyo) 114: 874-878, 1993. PMID: 8138545